GeneSet EGFR downregulation (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
--- -2.3 0.04098 19.0 6.0 2.33
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000196961 AP2A1 ---
ENSG00000006125 AP2B1 ---
ENSG00000161203 AP2M1 ---
ENSG00000042753 AP2S1 o--b
ENSG00000102606 ARHGEF7 NonAssociatedWithProgression
ENSG00000110395 CBL o--b
ENSG00000070831 CDC42 +oo
ENSG00000122705 CLTA +-o
ENSG00000141367 CLTC -o-
ENSG00000063245 EPN1 ---
ENSG00000085832 EPS15 +-o
ENSG00000127527 EPS15L1 ---
ENSG00000177885 GRB2 NonAssociatedWithProgression
ENSG00000185359 HGS o--b
ENSG00000143947 RPS27A o+o
ENSG00000147010 SH3KBP1 +o+
ENSG00000164056 SPRY1 +o+
ENSG00000136158 SPRY2 o+o
ENSG00000136738 STAM NonAssociatedWithProgression
ENSG00000115145 STAM2 o+o
ENSG00000221983 UBA52 o--a
ENSG00000170315 UBB ---