PEACHi
GeneSet Unfolded Protein Response (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--a -2.9 0.01877 51.0 15.0 7.24
DownRegulated -2.6 0.04051 51.0 39.0 30.12
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000072778 ACADVL o--b
ENSG00000087274 ADD1 +o+
ENSG00000162772 ATF3 +-o
ENSG00000128272 ATF4 o--b
ENSG00000118217 ATF6 o--a
ENSG00000159720 ATP6V0D1 o--a
ENSG00000074842 C19orf10 o-o
ENSG00000179218 CALR ---
ENSG00000175215 CTDSP2 o-+
ENSG00000044090 CUL7 ---
ENSG00000154832 CXXC1 o--a
ENSG00000172795 DCP2 o-o
ENSG00000204843 DCTN1 ---
ENSG00000175197 DDIT3 +-o
ENSG00000013573 DDX11 o--a
ENSG00000083520 DIS3 o--a
ENSG00000090520 DNAJB11 NonAssociatedWithProgression
ENSG00000128590 DNAJB9 o--b
ENSG00000102580 DNAJC3 NonAssociatedWithProgression
ENSG00000134109 EDEM1 o--b
ENSG00000172071 EIF2AK3 NonAssociatedWithProgression
ENSG00000134001 EIF2S1 o--a
ENSG00000171311 EXOSC1 NonAssociatedWithProgression
ENSG00000130713 EXOSC2 o--b
ENSG00000107371 EXOSC3 NonAssociatedWithProgression
ENSG00000178896 EXOSC4 --o
ENSG00000077348 EXOSC5 o--a
ENSG00000223496 EXOSC6 o--a
ENSG00000075914 EXOSC7 NonAssociatedWithProgression
ENSG00000123737 EXOSC9 o--b
ENSG00000012232 EXTL3 o-o
ENSG00000106080 FKBP14 -+o
ENSG00000198380 GFPT1 NonAssociatedWithProgression
ENSG00000105723 GSK3A ---
ENSG00000143321 HDGF ---
ENSG00000051108 HERPUD1 +oo
ENSG00000166598 HSP90B1 NonAssociatedWithProgression
ENSG00000149428 HYOU1 o--b
ENSG00000088247 KHSRP o--b
ENSG00000124702 KLHDC3 o--a
ENSG00000140943 MBTPS1 o++a
ENSG00000012174 MBTPS2 oo+
ENSG00000001167 NFYA NonAssociatedWithProgression
ENSG00000120837 NFYB o-o
ENSG00000066136 NFYC NonAssociatedWithProgression
ENSG00000140694 PARN o-o
ENSG00000065485 PDIA5 NonAssociatedWithProgression
ENSG00000143870 PDIA6 o-o
ENSG00000068971 PPP2R5B NonAssociatedWithProgression
ENSG00000138073 PREB o--a
ENSG00000138674 SEC31A o+o
ENSG00000120742 SERP1 --o
ENSG00000160691 SHC1 o--a
ENSG00000182934 SRPR o--a
ENSG00000144867 SRPRB NonAssociatedWithProgression
ENSG00000124783 SSR1 -+o
ENSG00000213599 SULT1A3 o--b
ENSG00000157014 TATDN2 o--a
ENSG00000137076 TLN1 NonAssociatedWithProgression
ENSG00000166340 TPP1 o--a
ENSG00000184205 TSPYL2 o--b
ENSG00000070540 WIPI1 o+o
ENSG00000100219 XBP1 -+o
ENSG00000174851 YIF1A o--a
ENSG00000116809 ZBTB17 o--b